Pentobarbital induces nocifensive hyperrflexia, not hyperalgesia in rats
نویسندگان
چکیده
منابع مشابه
Hibernation induces pentobarbital insensitivity in medulla but not cortex.
The 13-lined ground squirrel (Ictidomys tridecemlineatus), a hibernating species, is a natural model of physiological adoption to an extreme environment. During torpor, body temperature drops to 0-4 degrees C, and the cortex is electrically silent, yet the brain stem continues to regulate cardiorespiratory function. The mechanisms underlying selective inhibition in the brain during torpor are n...
متن کاملKetamine does not affect intestinal microcirculation in pentobarbital-anaesthetized rats during experimental endotoxaemia.
The objective of the study was to evaluate the effects of ketamine on intestinal microcirculation in pentobarbital-anaesthetized rats during experimental endotoxaemia. A prospective, randomized, controlled study was carried out using 32 male Lewis rats. The animals were divided into four groups (n = 8 each). All animals were initially anaesthetized with 60 mg/kg pentobarbital (i.p.). Group 1 se...
متن کاملInhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats
BACKGROUND We have previously shown a sprouting of sympathetic fibers into the upper dermis of the skin following subcutaneous injection of complete Freund's adjuvant (CFA) into the hindpaw. This sprouting correlated with an increase in pain-related sensitivity. We hypothesized that this sprouting and pain-related behavior were caused by an increase in nerve growth factor (NGF) levels. In this ...
متن کاملCorrection: Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats
Correction It was brought to my attention that the representative bands on Figure 1A, of this work [1] are from a different experiment than the one described and do not represent the quantified data. The quantification and bar graphs are correct, but the representative bands should be replaced by the ones from the corresponding experiment. The error was made during figure preparation. We apolog...
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BACKGROUND There are numerous studies implicating that EphB receptors and ephrinB ligands play important roles in modulating the transduction of spinal nociceptive information. EphrinB-EphB signaling may contribute to hyperalgesia via various kinds of downstream molecules, the mechanisms of which have not been completely understood. OBJECTIVE The aim of the present study was to identify wheth...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2000
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03019003